Why chemotherapy is not necessary for every breast cancer and which tumour and patient factors shape systemic treatment decisions.
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Chemotherapy is not automatic after a breast cancer diagnosis. Decisions depend on tumour size and grade, lymph nodes, hormone receptors, HER2 status, age, menopausal status, general health and sometimes a validated genomic assay.
Some patients gain more benefit from endocrine therapy, HER2-targeted treatment, surgery and radiotherapy without chemotherapy. The recommendation should follow complete staging and multidisciplinary review rather than one result in isolation.
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